Working Group Pepelanova - Biomaterials for regenerative therapy
Focus of research in AG Pepelanova is the development of biotechnological processes for the production of materials for regenerative medicine applications. We develop biomaterials based on proteins from the extracellular matrix (ECM), which can then be used to construct inductive scaffolds for tissue engineering and 3D mammalian cell cultivation. The design process starts by selecting bioactive sequences from structural proteins like fibrinogen and collagen and subsequent production of the targets in GRAS organisms like E. coli and P. pastoris. Further chemical modification imparts the biological polymers with specific mechanical properties. Apart from our work with structural proteins from the ECM, an additional topic of research is the production and characterization of recombinant enzymes which play a role in tissue regeneration. Our group is part of the “Material Development” module within the joint research initiative “Biofabricaiton for NIFE” and is carried out in close cooperation with clinical researchers.